NADP+

NADP+ is the oxidized form of the electron donor nicotinamide adenine dinucleotide phosphate.

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NADP+ is the oxidized form of the electron donor nicotinamide adenine dinucleotide phosphate. NADP+ together with its reduced form, reduced NADPH, is involved in maintaining redox balance and supporting the biosynthesis of fatty acids and nucleic acids [1].

NADP+, a structural analogue of NAD+, is synthesized by transferring a phosphate group from ATP to the 2′-hydroxyl group of the adenosine ribose moiety of NAD+. This reaction is catalyzed by NADKs [2]. NADP+ act as a cofactor in various biological reactions [3]. NADP+/NADPH is important in regulating the cellular redox state, energy metabolism, mitochondrial function, gene expression, and signaling pathways, NADP+/NADPH are essential for maintaining a large array of biological processes[3,4,5].

References:

[1]. Yang, Yue, and Anthony A. Sauve. "NAD+ metabolism: Bioenergetics, signaling and manipulation for therapy." Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1864.12 (2016): 1787-1800.

[2]. Ying, Weihai. "NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences." Antioxidants & redox signaling 10.2 (2008): 179-206.

[3]. Jackson J B. A review of the binding-change mechanism for proton-translocating transhydrogenase[J]. Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2012, 1817(10): 1839-1846.

[4]. CantÓ, Carles, and Johan Auwerx. "NAD+ as a signaling molecule modulating metabolism." Cold Spring Harbor symposia on quantitative biology. Vol. 76. Cold Spring Harbor Laboratory Press, 2011.

[5]. CantÓ, Carles, Keir J. Menzies, and Johan Auwerx. "NAD+ metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus." Cell metabolism 22.1 (2015): 31-53.

Chemical Properties

Cas No. 53-59-8 SDF

Synonyms Coenzyme II, β-NADP, Nicotinamide adenine dinucleotide phosphate, TPN

Chemical Name adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'→5'-ester with 3-(aminocarbonyl)-1-β-D-ribofuranosylpyridinium, inner salt

Canonical SMILES O[C@H]1[C@@H](OP(O)(O)=O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP(OP(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H]([N+]5=CC(C(N)=O)=CC=C5)O4)([O-])=O)(O)=O

Formula C21H28N7O17P3 M.Wt 743.4

Solubility Soluble in PBS, PH7.2, 10mg/mL Storage Store at -20°C,protect from light

General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.

To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.

Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.